Association between a Polygenic Risk Score for Multiple Myeloma Risk and Overall Survival

PRSice: Polygenic Risk Score software

SUMMARY A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in un...

Schizophrenia polygenic risk score and psychotic risk detection.

Improving overall survival and overcoming adverse prognosis in the treatment of cytogenetically high-risk multiple myeloma.

Multiple myeloma (MM) is a heterogeneous disease with certain genetic features [e.g., t(4;14), del17p] associated with worse outcome. The introduction of thalidomide, lenalidomide, and bortezomib has dramatically improved the outlook for patients with MM, but their relative benefit (or harm) for different genetic patient subgroups remains unclear. Unfortunately, the small number of patients in ...

Association between the Risk Factors for Atherosclerosis and Diverticular Bleeding

Background and purpose: Diverticulosis is a major health problem in middle-aged and older adults. The cause of bleeding in the diverticulum is not clear, but arteriolar changes are considered as the main pathogenesis of diverticular bleeding. This study aimed at investigating the relationship between the risk factors for atherosclerosis and diverticular bleeding. Materials and methods: In this...

Relationship between diet diversity score and breast cancer risk

Background: The average age of women with breast cancer in Iran is at least 10 years lower in comparison to developed countries and the incidence of the disease in Iranian women is on a rise. According to studies, diets that are diverse in food groups can play a role in protecting against chronic diseases including cardiovascular diseases and cancer. Diet diversity score is an indicator used to...